ea0049ep745 | Endocrine Disruptors | ECE2017
Charazac Aurelie
, Deconde Le Butor Celia
, Gueye Mamadou
, Gilleron Jerome
, Giulietti Kevin
, Fenichel Patrick
, Descombes Xavier
, Bost Frederic
, Clavel Stephan
, Chevalier Nicolas
Persistent organic pollutants (POPs) are environmental contaminants that interfere with normal hormonal homeostasis and act as endocrine disrupting compounds (EDC). These molecules can mimic hormone effects on metabolism. The links between metabolism and cancer are now well established. Metabolism generates reactive oxygen species (ROS), which contribute to mutations and induces oncogenic transformation. In turn, cancer cells display high metabolic flexibility allowing them to...